This reply was written with the help of a scientist.
Concerning Orgel’s biographical memoirs,
http://www.nasonline.org/publications/biographical-memoirs/memoir-pdfs/orgel-leslie.pdf:
The author makes a significant statement in it,
Orgel never achieved, and to this day no one has achieved, the residue-by-residue copying of RNA in a sequence-general manner. Thus, his vision of “replicative doodling” has yet to be realized experimentally.
Residue-by-residue copying is the basis for what is called the “RNA World” in origin-of-life theory. It has been proposed because of necessity if a natural origin is true, even though the arguments against it are numerous and severe. However, the only alternative is for a simultaneous appearance of protein and RNA replication, which is so complex with interrelated RNA and protein interactions that the staunchest of evolutionists recognizes its implausibility.
Not a single major component of RNA replication can be successfully demonstrated. Even seemingly small steps of progress are overwhelmed by insurmountable problems. Prebiotic experiments reveal many plausibly fatal roadblocks and no demonstrable solutions—they are roadblocks.
A person believes in a natural origin of life because he wants to despite the observed scientific evidence—not because of it.
There is a reason successful RNA replication of an RNA replicator template has not been achieved as the above article on Orgel mentioned. It takes over 200 nucleotides to build an RNA molecule capable of copying an RNA template accurately. Yet, RNA degrades so rapidly and the copying process is so slow that the copying molecule (replicator) falls apart before it can copy the template. Hence, if the template is for a replicator, it too will tend to degrade, falling apart before it can be copied. If this cannot be done in the lab under idealized, controlled conditions, the likelihood of it actually taking place in a natural, uncontrolled environment is virtually nil.
It does not do any good to have a single suitable replicator spontaneously appear. There also needs to be a template of its complement appear simultaneously. Furthermore, the replicator needs to be free and available to copy the template instead of being busy with another template and then needs to find the template and start copying it before either the replicator or the complement fall apart. Otherwise, all progress is lost.
In an environment offering many random attempts to form a suitable nucleotide sequence to produce a replicator, there will be many long strings which do not replicate. As the longer ones degrade, there becomes an overwhelming number of short ones in the solution. All of these are vying for the “attention” of the replicator when it becomes available to start working on a string.
There are many, many, many ways to randomly make long strings of nucleotides that do not work. After decades of intensive research, science still cannot make a replicator able to replicate a template of itself. There is no basis to expect in a solution with so many “parasites” that a second replicator would appear in a timely manner and close enough to be the one replicated.
Adding to this complexity is the problem of complementarity. RNA replicates the complement of its template. This requires two successful passes for a replicator to make a useful copy of itself. This is just not feasible from what scientific observation teaches us. A person believes it because he wants to, but not because of observed science teaching its feasibility under even the most favorable conditions.
Adding to this is the issue that scientists can start with the most ideal natural chemicals possible, work on them with the most ideal energy sources possible, in the most ideal environment possible, and still cannot get nucleotides to appear spontaneously without lots of human intervention. Nature is not so considerate. Science reveals all kinds of problems that would plausibly prevent nucleotides appearing in a form pure enough to use. Furthermore, until life itself appears, there are no feedback control mechanisms to keep the ratios between nucleotide species in anywhere near to being in usable ratios.
In fact, Orgel himself alluded to this problem. The article mentions, “He never hesitated to point out aspects of the prebiotic synthesis of RNA that remained unresolved, especially the difficulty in forming RNA without generating complex mixtures of related compounds that would interfere with RNA replication.” Yes, the prebiotic synthesis of RNA remains unsolved. However, the issue is not one of ignorance, that we haven’t figured out the problem. Instead, extensive investigation has revealed a long series of roadblocks which would naturally thwart its appearance. The problem is not the evidence. It is the unwillingness of Orgel and others to acknowledge the evidence.
These are just of a few of the problems discussed in the article by Dr. George Matzko, A Natural Origin-of-Life: Every Hypothetical Step Appears Thwarted by Aniogenetic Randomization, posted at
https://www.osf.io/p5nw3, and alluded to earlier.
If science makes an overwhelming case against the possibility of a natural origin of life, then there would be nothing for evolution to work with.
So, a question: Can you or anyone falsify the problem of randomization, the foundational premise of the Matzko article? Scientific papers, such as the one by Matzko are never accepted for publication in the standard science journals. They are typically rejected without comment. This is expected. If the foundational premise is true, then materialism is without basis and the entire false focus of modern science is exposed. Modern science defines science as the best explanation consistent with a
materialistic perspective.
Hence, if any observations appear to challenge materialism they are rejected without comment. Yet, in its public presentation the assertion is constantly made that science affirms materialism. There is a twist here: science as defined by materialists is only allowed to confirm materialism and so it does. Unbiased science shows the error of this method, but these arguments are only ridiculed, then ignored by materialists. So, can you or anyone here falsify the underlying premise of Matzko’s article from an honest perspective based on true science? I.e., science as understood before Darwin and Huxley hijacked it into a tool to promote materialism? In other words, can you accept the evidence at face value and let it lead to where it naturally leads?
The historical attitude of the early scientists who founded the various fields (Boyle, Faraday, Gauss, etc.) was that a living God created the universe out of nothing, using His innate power as God. He established an order in His creation which allows an orderly operation and progression of events. However, He can intervene and override any aspect of the creation at His will—in any manner and at any time. And He does this. Obviously, science is by definition the study of this natural order. The creation cannot determine what the God who created it will choose to do next, so science does not have the tools to predict His behavior. However, such a God can reveal Himself through the creation, doing so in a manner that HE chooses for His purposes.
One way of revealing Himself is represented by Matzko’s article: the study of the creation reveals a fundamental principle of natural law—randomization—that works against a natural origin of life at every step. This is one aspect of how He reveals Himself to man. In this case, the task of the atheist is to invalidate the fundamental principle dealing with the issues honestly. It would actually take only one insurmountable step to render the appearance of life impossible. Yet, it appears that randomization proves fatal to every step examined.
Moreover, randomization is actually the underlying root for what is called entropy. The discussion is too deep for here, but just be aware that there are no observed instances where entropy is violated.
Hence, a person really first needs to invalidate the root principle underlying entropy in order to make a case that natural processes are adequate to create life.
Concerning “Orgel’s rules.” These are only generalized statements. They have not been rigorously analyzed or defined, which is what is needed for true scientific value. For instance, he talks about how a certain protein evolved into a form which allows it to meet a special need. Scientific analysis would quantify what the starting protein sequence was and the changes needed to convert it into a new form meeting a new need. Common sense suggests that if minor changes are adequate and the opportunities for them to appear are great enough, they will probably appear. However, the greater the divergence between the two proteins, the more unlikely it is for the change to appear. True science is quantifying an issue like this and determining its validity. Fake science latches onto anything that supports its agenda and trumpets it as long and as loudly as it can get away with.
In other words, there are limits. Undefined statements such as Orgel’s Rules made without any attempt to define limits or made in an effort to gloss over limits because of an agenda are meaningless at best. For instance, hemoglobin is a protein. So is an antibody. Both are completely different in structure and purposes. Can one imagine a reasonable path where an organism needing a particular antibody could modify hemoglobin to provide it? Orgel’s rules appear to have very limited applicability.
There is no basis to suggest they are adequate to account for the changes necessary to transform any known taxonomic class into a different known one. The changes needed are too great in character and quantity to assert that Orgel’s Rules are adequate to account for all of the simultaneous changes needed.
Any claims to the contrary are only speculations presented as fact.