Quote from JezLiberty:
Blow-up: see Amaranth, LTCM, Niederhoffer, etc. basically holding positions that go the wrong way and keeping holding until the losses are too big that they "blow up" and force you to unwind the position and close the fund.
Typically happens with Option-writing strategies: look (very) good until they blow up by a Black Swan event.
This never happens with Trend Following thanks to the use of stop losses - of course there can also be large drawdowns resulting from many small losses, but the art of Money Management is to make sure that these strings of small losses keep you in the game until the next big moves..
Not sure that Dunn, JWH, Chesapeake, Abraham, Eckhardt, etc. use anything else than Trend Following at the root of their strategy...