Quote from Echieo:
I imagine a single trade with high leverage could pose a serious risk to your entire account unless you set your stops very close to your entry points (which isn't always practical).
No, this is wrong, leverage should affect neither your stop price nor your target price but only your capitalization. It is the number of shares/contracts that could change in the presense of leverage but not necessarily so.
The number of shares/contracts is equal to N = PR X C/SL, where PR is the percent risk per trade, for example 0.02 for 2%, C is the available cash and SL the loss in case the stop loss is hit. In the formula you must use the value of the cash account.
The leverage determines the maximum shares/contracts you can buy or sell as follows
Nmax = C x L / P where P is the price, C is the available cash and L is the leverage.
If N > Nmax, then set N = Nmax and that only has the effect of lowering your risk to
PR' = Nmax x SL /C which is < PR
For example if you trade equities and you have 10K in the account and the leverage factor is 4, your percent risk is 2%, or 0.02, and the stop loss value is $1 then
N = 10,000 x 0.02/1 = 200 shares. Simply, if you lose $1 per share you lose a total of $200 which is equal to 2% of your account.
The maximum number of shares you can buy on leverage is:
Nmax = 10K x 4 /P,
If P = $100 then Nmax = 400 and you can trade the 200 shares. But if P = $300 (something like GOOG*), then Nmax = 133.33 and you can only trade that much because you are limited by your account capitalization for that particular trade.
In case of short equities you should also take into account other regulations for capitalization.
The derivation of the position sizing formula for percent risk can be found in this paper by Michael Harris, which I recommend you read:
http://www.tradingpatterns.com/PositionSizing.pdf
* of course, you wouldn't place a $1 stop in GOOG, this is just an example to illustrate the formula use.