I get very nervous trading large notional positions in my own account. Last week I put on a DITM bull call spread in PCLN, with what I perceived was positive expectancy. Because it was a tight spread, the P/L at expiry was something I could handle in terms of my account size, but the giant swings in the options gave me fits. Each side of the trade at any time could be up or down roughly the size of my account. Because it was a debit spread and the short leg was still ITM, I hung on tight. (Part of the instantaneous P/L is affected by my broker using bid and ask prices on long and short positions, so it always looks worse than reality, but still.)
Eventually PCLN dumped below my short strike and I closed out for a small loss. That said, there is no freakin' way I could be trading billion dollar combos, even if weren't my own money. An investment banker I am not.