Advantage of Spreads vs Vanilla?

What is the advantage of using spreads vs just deciding upon a strike and buying those puts/calls for a move?

I don't get what the advantage is of buying say three calls at three different strikes vs just buying three calls at the middle strike of those three...

Personally I prefer 1ITM or 1OTM. If playing weeklies I always stick with 1ITM or very close to that.
 
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