Is this quote presented as pro-Christianity or anti-Christianity? If the latter as I suspect, it is more out of context rabbit droppings. I said that to start and I'm still saying it and people are still offering it up and I will keep batting them out of the park.Quote from RewriteQuran:
"Religion was born when the first con man met the first fool." --Mark Twain
Twain was a Presbyterian. His views on theology developeded throughout his life, he attended church and engaged in religious discussions. I would bet this quote stems from one of those religious discussions, where he's commenting on how religion is used to manipulate people instead of enlighten them. In context probably the exact opposite as it is being presented here, although I haven't looked it up and don't plan to. He believed in God and constantly struggled with scripture, how things should be yet are not and had varying opinions on religion throughout his life.
Although he wrote some materials that seemed to ridicule Christianity he also raised or helped raise money to build a church. Apparently he was also a Freemason. All in all, it's impossible to portray him as anti- Christian over all without lying by omitting contrary evidence.