Quote from bxptone:
THIS IS WHY AMERICA WILL FAIL, WHAT ASS BACKWARDS THINKING AND WHAT A WASTE OF MONEY!!!
How many people have EVER overdosed smoking weed?
How many people enter the emergency room with a MARIJUANA EMERGENCY?!
Meanwhile the government will POSION ITS OWN CITIZENS THROUGH THE SALE OF CIGARETTES IN ORDER TO MAKE REVENUE THROUGH TAXES, FUCKING DISGUSTING. And when you die from smoking it's usually in the from of cancer or emphysema. So not only do you get charged an arm and a leg to smoke your whole life away, YOU GET TO BASICALLY SUFFOCATE TO DEATH THROUGH LUNG CANCER OR EMPHYSEMA.
NICEEEEEEEE
Anyone want to even try to estimate how many TRILLIONS of dollars it's cost Americans over the past say 60 years to treat lung cancer patients.
DO YOU KNOW THERE ARE REPORTS, FEDERAL REPORTS, THAT CLAIM MARIJUANA MIGHT PREVENT CANCER, TRUE FUCKING STORY.
CAN'T SMOKE WEED WHO MAKES PEOPLE RELAX, BUT DRINK AS MUCH FUCKING ALCHOL AS YOU CAN, SO YOU...
BEAT YOUR WIFE
GET HUNG OVER AND CAN'T PERFORM AT YOUR JOB
GET DRUNK, CRASH YOUR CAR AND KILL A FAMILY OF 5
DESTROY YOUR OWN FAMILY
GET ONE OF THE MANY DISEASES ASSOCIATED WITH ALCHOLISM, SO AGAIN YOU CAN RAPE THE AMERICAN TAX PAYER/HEALTH CARE SYSTEM...
AND THEN WHEN YOU CAN'T STOP DRINKING, BECAUSE YOUR LIFE IS GOING DOWN THE TOILET, DONT TAKE ANY BLAME, CHALK IT UP TO SOME DISEASE SO YOU CAN DRINK THE REST OF YOUR LIFE AWAY! LMFAOOOOOOO
THIS COUNTRY IS AS ASS BACKWARDS AS IT GETS.
Quote from tradersboredom:
weed, coke, heroin, whisky 40 %, tranquilers, viagra.
all bad drugs. fucks up your mind if abused
There is great interest in endocannabinoids for their role in neuroplasticity as well as for therapeutic use in numerous conditions, including pain, stroke, cancer, obesity, osteoporosis, fertility, neurodegenerative diseases, multiple sclerosis, glaucoma and inflammatory diseases, among others. However, there has been relatively far less research on this topic in the eye and retina compared with the brain and other organ systems.
Cannabinoids have been found to have antioxidant properties, unrelated to NMDA receptor antagonism. This new found property makes cannabinoids useful in the treatment and prophylaxis of wide variety of oxidation associated diseases, such as ischemic, age-related, inflammatory and autoimmune diseases.
Assignee: The United States of America as represented by the Department of Health and Human Services
It has been proposed that cannabinoids are involved in the control of cell fate. Thus, these compounds can modulate proliferation, differentiation, and survival in different manners depending on the cell type and its physiopathologic context. However, little is known about the effect of cannabinoids on the cell cycle, the main process controlling cell fate. Here, we show that {Delta}9-tetrahydrocannabinol (THC), through activation of CB2 cannabinoid receptors, reduces human breast cancer cell proliferation by blocking the progression of the cell cycle and by inducing apoptosis.
Cannabinoids (CBs) have been found to exert antiproliferative effects upon a variety of cancer cells, including colorectal carcinoma cells. However, little is known about the signalling mechanisms behind the antitumoural effect in these cells, whether the effects are shared by endogenous lipids related to endocannabinoids, or whether such effects are synergistic with treatment paradigms currently used in the clinic.
After 20 hours of treatment, Δ9-THC kills all cancer cells but leaves normal brain cells alive. Cell death is evidenced by cells shrinking to inanimate white spheres.
It has been recently shown that cannabinoids, the active components of marijuana and their derivatives, inhibit cell cycle progression of human breast cancer cells. Here we studied the mechanism of Delta(9)-tetrahydrocannabinol (THC) antiproliferative action in these cells, and show that it involves the modulation of JunD, a member of the AP-1 transcription factor family. THC activates JunD both by upregulating gene expression and by translocating the protein to the nuclear compartment, and these events are accompanied by a decrease in cell proliferation.