Hi Newguy.
You can trade a variety of markets. If your looking for weekends and or evenings you basically looking at Sunday night about post 6 PM ET. Mostly futures and forex. The leverage is great but it cuts both ways. If you want to do Nadex you can check out the forex pairs on sunday night they have binaries with expirations every hour on some instruments and spreads on every instrument.
Most people from what i have seen when commenting on nadex don't understand the product. They think you hold till expiration not understanding you can exit. They don't know they have spreads. They don't konw you can do high probability ITM binaries and manage the risk. OR high payout OTM binaries and have no stop loss. Also the pricing model is a mystery to most but its just a delta of a call options with same strike expiration.
I trade them regularly if you have questions let me know will be glad to help if i can.
Then you probably know that the Nadex binaries are simply synthetic vanilla verticals that are poorly priced.