To be honest, I'm not 100% sure. I don't see why not. My setup is 2 monitors connected to the box. The right monitor I have my charts and the left monitor is my TWS/email/web/msn etc
There is a great little programme called 'Ultramon' It allows you to run multi monitor setups. For example:
1). Different desktop background on each monitor.
2). Set a certain programme to a certain monitor.
3). Switch programmes between monitors using hotkeys